Sci 9 Lesson 8 April 18 - Assisted Reproductive Technologies
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This document provides information about assisted reproductive technologies (ART). It defines infertility as the inability of a couple to have a baby. It describes some common ART procedures like artificial insemination, in vitro fertilization, gamete intrafallopian transfer, and intracytoplasmic sperm injection. It also discusses some ethical issues surrounding ART like risks of birth defects and what to do with leftover embryos. The document provides homework assignments related to learning about reproduction.
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BAIBYS™ Fertility company presentation
One-Liner
BAIBYS™ develops an AI and robotics-based COMPLETELY AUTONOMOUS system for sperm selection for IVF, which will improve success rates, reduce birth defects, and raise clinics’ throughput.
The problem
According to the WHO guidelines, in a healthy man, 96% of the sperm cells are abnormal. Natural fertilization overcomes this problem by having millions of sperm cells compete on one egg through various selection processes such that only the best one wins. However, in IVF today, the injected sperm cells are selected arbitrarily. Thus, the natural sperm selection process is bypassed, leading to fewer successful pregnancies and more birth defects. A manual selection at high magnification was proposed, showing higher success rates and reduced birth defects (NEJM, 2001). Nevertheless, this manual procedure was not widely adopted since it was lengthy (3h vs. a few minutes), subjective and inconsistent, required extensive training, and was therefore expensive.
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Assisted Reproductive Technology
ART involves surgically extracting eggs from a woman's ovaries, fertilizing them with sperm in a lab, and returning the embryos to the woman's body or donating them. There are various causes of infertility that ART can treat, such as blocked fallopian tubes or male factor infertility. Common ART procedures include IVF, where fertilization occurs outside the body, and ICSI, where a single sperm is injected into an egg. IVF involves stimulating a woman's ovaries, retrieving eggs, fertilizing them in vitro, and transferring embryos back into the uterus. ART can have risks like multiple pregnancies or ovarian hyperstimulation. Counseling supports patients through the psychological impacts of infertility and ART.
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This document discusses in vitro fertilization (IVF), including:
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- Why it is used, typically for issues like damaged fallopian tubes or male factor infertility
- Benefits like helping more people have families but also concerns like health risks of multiple pregnancies
- The social impacts, including lack of regulation for surrogacy which led to legal dilemmas, and debates over stem cell research and "creating immortality"
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- What IVF is and a brief history of its development
- Why it is used, typically for issues like damaged fallopian tubes or male factor infertility
- Who commonly uses IVF and some benefits it provides
- Social and health concerns associated with IVF, such as multiple pregnancies or views of IVF being unnatural
- The social impacts of issues like lack of regulation for surrogates and debates around stem cell research from IVF embryos
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Birthdefect risk following assisted reproductive technology
1) ART procedures like IVF are associated with an increased risk of preterm birth, low birth weight, and multiple births compared to spontaneously conceived pregnancies. Studies have also found an increased risk of birth defects, though results are inconsistent.
2) The risk of birth defects may be 1.5-2 times higher in ART pregnancies compared to non-ART pregnancies. Certain defects like gastrointestinal and cardiovascular defects appear to have a significantly higher risk.
3) The causes of increased birth defect risk are unknown but could include the ART procedures themselves damaging embryos, genetic issues in infertile patients, or imprinting defects from embryo culture media or abnormal sperm imprinting. Larger, more rigorous studies are still needed
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Infertility affects approximately 15% of couples in North America due to issues like low sperm counts, hormone imbalances, or damage to eggs or sperm. Assisted reproductive technologies (ART) allow many infertile couples to conceive, including artificial insemination (AI), in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and intracytoplasmic sperm injection. IVF involves collecting eggs and sperm and fertilizing the egg in a petri dish before implanting the embryo in the woman's uterus, while GIFT and intracytoplasmic sperm injection directly inject gametes or embryos in the body. ART can help couples conceive when natural conception is impossible due to issues with the
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Similar to Sci 9 Lesson 8 April 18 - Assisted Reproductive Technologies
BAIBYS™ Fertility company presentation
One-Liner
BAIBYS™ develops an AI and robotics-based COMPLETELY AUTONOMOUS system for sperm selection for IVF, which will improve success rates, reduce birth defects, and raise clinics’ throughput.
The problem
According to the WHO guidelines, in a healthy man, 96% of the sperm cells are abnormal. Natural fertilization overcomes this problem by having millions of sperm cells compete on one egg through various selection processes such that only the best one wins. However, in IVF today, the injected sperm cells are selected arbitrarily. Thus, the natural sperm selection process is bypassed, leading to fewer successful pregnancies and more birth defects. A manual selection at high magnification was proposed, showing higher success rates and reduced birth defects (NEJM, 2001). Nevertheless, this manual procedure was not widely adopted since it was lengthy (3h vs. a few minutes), subjective and inconsistent, required extensive training, and was therefore expensive.
BAIBYS’ solution
BAIBYS’ system performs the same selection process, based on the same well-accepted criteria, COMPLETELY AUTONOMOUSLY, in a fraction of the time and cost of the current manual process. The user needs only to place a cartridge with the sperm sample into the console and press a button, and the system will autonomously identify the optimal cells and will robotically transfer them to a separate droplet in the cartridge. Eliminating the drawbacks of the manual process by making it fast, objective, consistent, without trained personnel, and affordable, would allow its use in every IVF cycle, improving success rates, and reducing birth defects, while raising the clinics’ throughput and reputation.
Impact
The system shall revolutionize the IVF process by reducing the financial and emotional crisis involved with it by saving failed IVF treatments, reducing the economic burden on health systems, raising IVF clinics throughput, making IVF more accessible globally, and most importantly, reducing birth defects and helping more families in having healthy babies.
Market
The global IVF market is estimated at $41B by 2026 and growing at >10% CAGR. With 5M IVF treatments in the world forecasted for 2026, at >$200 disposable cartridge cost, plus consoles and service sales, BAIBYS’ Total Addressable Market exceeds $1B.
Progress
After a seed round of $2M in Q1/2021 (mostly from angels who are international experts in andrology and fertility clinic owners) and completing a working prototype, we closed an additional $2M investment by an Israeli VC to lead a $3-4M round. The use of proceeds is to develop the product, conduct clinical trials, and get regulatory clearances. Our seed round investors participated in this round as well.
Art.
ART involves medical techniques like drug therapy, artificial insemination, and IVF to treat infertility. Key ART procedures include IUI, IVF, ICSI, and surrogacy. The first successful human IVF resulted in Louise Brown's birth in 1978. While ART has helped many conceive, it also presents risks like multiple births, infection, and complications for mother and baby. Ongoing research aims to improve outcomes and access to these important infertility treatments.
Techniques involved in assisted reproductive technology
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Assisted Reproductive Technologies
Assisted reproductive technologies (ART) are a range of techniques used to help with infertility by manipulating eggs and sperm outside of the body. Major techniques include artificial insemination, in vitro fertilization and embryo transfer, gamete intrafallopian transfer, zygote intrafallopian transfer, intracytoplasmic sperm injection, and cloning. ART can help couples with infertility issues like tubal disease, endometriosis, immunological causes, or male factor infertility conceive children.
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Since the birth of Louise Brown, the first baby born through in vitro fertilization, in 1978, assisted reproductive technology has advanced significantly. The success rate of in vitro fertilization (IVF) has risen dramatically over the last four decades as a result of developments in incubation methods, micromanipulation technology, and a general understanding of assisted reproduction.
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The document discusses the importance of assisted reproductive biotechnology in humans and animals. It notes that about 1 in 6 couples is infertile in the US and look to clinics in India and Asia for help. It also discusses efforts to save endangered species like the Pashmina goat and wild buffalo through cloning techniques. The document then goes on to discuss various causes of male and female infertility and techniques used in assisted reproduction like IVF, ICSI, and embryo transfer.
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Learn all about Assisted Reproductive Techniques by this presentation. It also contains the extra notes for the the speaker itself which would help to describe better !!
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This document discusses various medically assisted reproductive technologies used to treat infertility, including intrauterine insemination (IUI), in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), zygote intrafallopian transfer (ZIFT), tubal embryo stage transfer (TET), and intracytoplasmic sperm injection (ICSI). It provides details on the general protocols and advantages and disadvantages of each technique. Causes of infertility and negative aspects of assisted reproductive technologies are also addressed.
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Assisted Reproductive Technology
ART involves surgically extracting eggs from a woman's ovaries, fertilizing them with sperm in a lab, and returning the embryos to the woman's body or donating them. There are various causes of infertility that ART can treat, such as blocked fallopian tubes or male factor infertility. Common ART procedures include IVF, where fertilization occurs outside the body, and ICSI, where a single sperm is injected into an egg. IVF involves stimulating a woman's ovaries, retrieving eggs, fertilizing them in vitro, and transferring embryos back into the uterus. ART can have risks like multiple pregnancies or ovarian hyperstimulation. Counseling supports patients through the psychological impacts of infertility and ART.
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- What IVF is and a brief history of its development
- Why it is used, typically for issues like damaged fallopian tubes or male factor infertility
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- The social impacts, including lack of regulation for surrogacy which led to legal dilemmas, and debates over stem cell research and "creating immortality"
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This document discusses designer babies. It defines a designer baby as one whose genetic makeup has been artificially selected through genetic engineering to ensure particular genes or characteristics. The first designer baby, Adam Nash, was born in 2000 using pre-implantation genetic diagnosis to screen embryos for genetic disorders prior to implantation. While designer babies allow for healthy children and gender selection, there are also moral, ethical, social, and safety concerns. Currently, fertility clinics in major US cities conduct research on prenatal genetic testing to eliminate diseases.
Ivf presentation
This document discusses in vitro fertilization (IVF), including:
- What IVF is and a brief history of its development
- Why it is used, typically for issues like damaged fallopian tubes or male factor infertility
- Who commonly uses IVF and some benefits it provides
- Social and health concerns associated with IVF, such as multiple pregnancies or views of IVF being unnatural
- The social impacts of issues like lack of regulation for surrogates and debates around stem cell research from IVF embryos
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A book review presentation on Baby-making : what the new reproductive treatments mean for families & society by Bart Fauser & Paul Devroey for H6792, Science & Technology Sources & Services.
Presented by Nurashikin Jasni & V Somasundram on 16 October 2012
Birthdefect risk following assisted reproductive technology
1) ART procedures like IVF are associated with an increased risk of preterm birth, low birth weight, and multiple births compared to spontaneously conceived pregnancies. Studies have also found an increased risk of birth defects, though results are inconsistent.
2) The risk of birth defects may be 1.5-2 times higher in ART pregnancies compared to non-ART pregnancies. Certain defects like gastrointestinal and cardiovascular defects appear to have a significantly higher risk.
3) The causes of increased birth defect risk are unknown but could include the ART procedures themselves damaging embryos, genetic issues in infertile patients, or imprinting defects from embryo culture media or abnormal sperm imprinting. Larger, more rigorous studies are still needed
Techniques of Artificial Insemination in Cow, Doe, Ewe and Chicken
This document discusses techniques for artificial insemination in various animal species. It begins by defining artificial insemination as the introduction of semen into the female reproductive tract by means other than sexual intercourse. Advantages include genetic improvement and disease control, while limitations include needing skilled personnel and lower conception rates than natural breeding. The techniques described include recto-vaginal insemination in cows, intravaginal or transcervical insemination in does, and various methods like intravaginal, transcervical, or laparoscopic intrauterine insemination in ewes. For chickens, semen is deposited into the vagina with the bird restrained and its abdomen pressed.
Ivf
In-Vitro Fertilization (IVF) is a process where egg is fertilized outside the body in a laboratory. IVF involves hormonal stimulation of the ovaries to develop multiple eggs, retrieval of eggs and sperm, fertilization of the eggs in vitro, and embryo transfer into the uterus. IVF can help couples with infertility issues like blocked or damaged fallopian tubes, low sperm count or motility, endometriosis, or ovulation disorders. The first successful IVF birth was in 1978 and has since helped many couples struggling with infertility problems have children.
6e art
Infertility affects approximately 15% of couples in North America due to issues like low sperm counts, hormone imbalances, or damage to eggs or sperm. Assisted reproductive technologies (ART) allow many infertile couples to conceive, including artificial insemination (AI), in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and intracytoplasmic sperm injection. IVF involves collecting eggs and sperm and fertilizing the egg in a petri dish before implanting the embryo in the woman's uterus, while GIFT and intracytoplasmic sperm injection directly inject gametes or embryos in the body. ART can help couples conceive when natural conception is impossible due to issues with the
Innovations & Breakthrough in IVF PART 3
This document discusses innovations and breakthroughs in in vitro fertilization (IVF). It covers the following topics in 3 sentences or less:
Genetic screening techniques like preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS) are discussed to select embryos without genetic disorders or the highest chance of implantation. Time-lapse monitoring is presented as a way to continuously monitor embryo development in real-time without disruptions. Stem cell therapy and its potential role in inducing ovarian regeneration and sustained ovarian function is briefly covered.
Similar to Sci 9 Lesson 8 April 18 - Assisted Reproductive Technologies (20)
Techniques involved in assisted reproductive technology
Techniques involved in assisted reproductive technology
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Assistive Reproductive Techniques By Shubham Kapadia
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Reproductive medicine & its medico legal importance
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Baby-making : what the new reproductive treatments mean for families & society
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Birthdefect risk following assisted reproductive technology
Techniques of Artificial Insemination in Cow, Doe, Ewe and Chicken
Techniques of Artificial Insemination in Cow, Doe, Ewe and Chicken
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Sci 10 Lesson 2 April 14 - Temperature, Thermal Energy and Heat
The document provides an overview of key concepts related to temperature, thermal energy, and heat transfer. It defines temperature as a measure of the average kinetic energy of particles, and thermal energy as the total energy of all particles including kinetic and potential energy. Heat is defined as the transfer of thermal energy between objects of different temperature. The document also describes the three main methods of heat transfer as conduction, convection, and radiation and provides examples of each.
Sci 9 Lesson 6 April 12 - Sexual Reproduction
The document provides information about sexual reproduction in organisms. It discusses the three stages of sexual reproduction: mating, fertilization, and development. It describes external and internal fertilization and provides examples. It also discusses pollination, embryonic development through the trimesters, and lists homework assignments related to the topic.
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The document provides information about sexual reproduction in organisms. It discusses the three stages of sexual reproduction: mating, fertilization, and development. It describes external and internal fertilization and provides examples. It also discusses pollination in plants, embryonic development in humans, and fetal development over the three trimesters. The homework assignments are to complete worksheets on meiosis and sexual reproduction.
Biol 11 Lesson 3 April 11 - Ch. 28 Crayfish Dissection
The document provides homework assignments for students, which include:
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2) Continuing to work on a Phylum Facebook project due the following week where students research and report on an assigned organism.
3) Beginning to make cue cards for the next chapter, due at an upcoming review day.
The document also provides links to virtual crayfish dissection resources and instructions to complete the actual lab and turn it in by the end of class. Students are assigned additional review and project work for the next class.
Sci 9A Lesson 5 April 7 - Meiosis
The document provides information about meiosis and reproductive systems. It begins with assigning homework on meiosis and reproductive systems and a upcoming quiz. It then discusses meiosis in three paragraphs - defining meiosis as cell division that produces gametes, the two stages of meiosis (Meiosis I and Meiosis II), and the outcome being four haploid daughter cells. It also mentions crossing over, independent assortment, and genetic diversity.
Sci 9A Lesson 5 April 7 - Meiosis
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Biol 11 Lesson 2 April 7 - Arthropoda Station Info Sheets
The document summarizes key arthropod groups - trilobites, crustaceans, chelicerates, and uniramians. Trilobites had segmented bodies and paired appendages. Crustaceans are diverse but generally have a hard exoskeleton, antennae, gills, and legs attached to gills. Chelicerates include spiders and have a cephalothorax, four pairs of walking legs, and specialized appendages like chelicerae. Uniramians include insects, centipedes, and millipedes, and have adaptations like wings, tracheal respiration, and specialized mouthparts and societies.
Sci 9 Lesson 4 April 6 - Meiosis
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Biol 11 Lesson 1 April 5 - Arthropoda (1)
The document provides an overview of arthropods, including:
1) Arthropods are a large phylum characterized by jointed appendages and an exoskeleton. They include insects, spiders, crustaceans, and others.
2) There are four subphyla of arthropods including trilobites, chelicerates, crustaceans, and insects/centipedes/millipedes.
3) Arthropods have segmented bodies and a nervous system concentrated in the head, as well as open circulatory and excretory systems. They molt to grow.
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Learning objectives:
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LOOPS in orthodontics t loop bull loop vertical loop mushroom loop stop loop
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